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SMC ID Date Medicine Submission Type Indication
SMC2726 07/10/2024 nivolumab (Opdivo) Non submission

In combination with cisplatin and gemcitabine for the first-line treatment of adult patients with unresectable or metastatic urothelial carcinoma.

SMC2725 07/10/2024 drospirenone (Slynd) Non submission

Contraception

SMC2724 07/10/2024 cemiplimab (Libtayo) Non submission

In combination with platinum‐based chemotherapy is indicated for the first‐line treatment of adult patients with NSCLC expressing PD-L1 (in ≥ 1% of tumour cells), with no EGFR, ALK or ROS1 aberrations, who have:
- locally advanced NSCLC who are not candidates for definitive chemoradiation, or
- metastatic NSCLC

SMC2685 07/10/2024 faricimab (Vabysmo) Abbreviated

For the treatment of adult patients with visual impairment due to macular oedema secondary to branched and central retinal vein occlusion (BRVO and CRVO).

SMC2678 07/10/2024 relugolix (Orgovyx) Full

- For the treatment of adult patients with advanced hormone-sensitive prostate cancer.
- For the treatment of high-risk localised and locally advanced hormone dependent prostate cancer in combination with radiotherapy.
- As neo-adjuvant treatment prior to radiotherapy in patients with high-risk localised or locally advanced hormone dependent prostate cancer.

SMC2674 07/10/2024 selinexor (Nexpovio) Full

In combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy.

SMC2689 07/10/2024 pembrolizumab (Keytruda) Full

As monotherapy for the adjuvant treatment of adults with non-small cell lung carcinoma who are at high risk of recurrence following complete resection and platinum‑based chemotherapy.

SMC2673 07/10/2024 selinexor (Nexpovio) Full

In combination with dexamethasone for the treatment of multiple myeloma in adult patients who have received at least four prior therapies and whose disease is refractory to at least two proteasome inhibitors, two immunomodulatory agents and an anti-CD38 monoclonal antibody, and who have demonstrated disease progression on the last therapy.

SMC2659 07/10/2024 rezafungin acetate (Rezzayo) Full

For the treatment of invasive candidiasis in adults. Consideration should be given to official guidance on the appropriate use of antifungal agents.

SMC2717 09/09/2024 zilucoplan (Zilbrysq) Non submission

As an adjunct to diet in adult patients with genetically confirmed familial chylomicronaemia syndrome (FCS) and at high risk for pancreatitis, in whom response to diet and triglyceride lowering therapy has been inadequate.

SMC2715 09/09/2024 pegcetacoplan (Aspaveli) Non submission

As monotherapy in the treatment of adult patients with paroxysmal nocturnal haemoglobinuria (PNH) who have haemolytic anaemia.

SMC2716 09/09/2024 volanesorsen (Waylivra) Non submission

As an adjunct to diet in adult patients with genetically confirmed familial chylomicronaemia syndrome (FCS) and at high risk for pancreatitis, in whom response to diet and triglyceride lowering therapy has been inadequate.

SMC2664 09/09/2024 ivosidenib (Tibsovo) Full

As monotherapy for the treatment of adult patients with locally advanced or metastatic cholangiocarcinoma with an IDH1 R 132 mutation who were previously treated by at least one prior line of systemic therapy.

SMC2669 09/09/2024 elranatamab (Elrexfio) Full

As monotherapy for the treatment of adult patients with relapsed and refractory multiple myeloma, who have received at least three prior therapies, including an immunomodulatory agent, a proteasome inhibitor, and an anti-CD38 antibody and have demonstrated disease progression on the last therapy.

SMC2667 09/09/2024 dabrafenib (Finlee) Full
  • In combination with trametinib for the treatment of paediatric patients aged 1 year and older with low-grade glioma (LGG) with a BRAF V600 mutation who require systemic therapy.

  • In combination with trametinib for the treatment of paediatric patients aged 1 year and older with high-grade glioma (HGG) with a BRAF V600 mutation who have received at least one prior radiation and/or chemotherapy treatment.
SMC2668 09/09/2024 teclistamab (Tecvayli) Full

As monotherapy is indicated for the treatment of adult patients with relapsed and refractory multiple myeloma (RRMM), who have received at least three prior therapies, including an immunomodulatory agent (IMiD), a proteasome inhibitor (PI), and an anti-CD38 antibody and have demonstrated disease progression on the last therapy.

SMC2649 12/08/2024 etranacogene dezaparvovec (Hemgenix) Full

For treatment of severe and moderately severe haemophilia B (congenital Factor IX deficiency) in adult patients without a history of Factor IX inhibitors.

SMC2654 12/08/2024 trifluridine tipiracil (Lonsurf) Full

In combination with bevacizumab for the treatment of adult patients with metastatic colorectal cancer (CRC) who have received two prior anticancer treatment regimens including fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapies, anti-VEGF agents, and/or anti-EGFR agents.

SMC2702 12/08/2024 fezolinetant (Veoza) Non submission

Treatment of moderate to severe vasomotor symptoms (VMS) associated with menopause.

SMC2704 12/08/2024 nivolumab (Opdivo) Non submission

Adjuvant treatment of adults and adolescents 12 years of age and older with Stage IIB or IIC melanoma.

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Publication due date SMC meeting date Medicine Submission Type Indication
11/11/2024 bismuth subcitrate potassium/metronidazole/tetracycline hydrochloride (Pylera) Abbreviated

In combination with omeprazole, for the eradication of Helicobacter pylori and prevention of relapse of peptic ulcers in patients with active or a history of H. pylori associated ulcers.

11/11/2024 tenecteplase (Metalyse) Abbreviated

In adults for the thrombolytic treatment of acute ischaemic stroke (AIS) within 4.5 hours from last known well and after exclusion of intracranial haemorrhage.

11/11/2024 02/04/2024 linzagolix (Yselty) Full

For treatment of moderate to severe symptoms of uterine fibroids in adult women of reproductive age

11/11/2024 somapacitan (Sogroya) Abbreviated
11/11/2024 01/10/2024 lebrikizumab (Ebglyss) Full

Treatment of moderate-to-severe atopic dermatitis in adults and adolescents 12 years and older with a body weight of at least 40 kg who are candidates for systemic therapy.

11/11/2024 quizartinib (Vanflyta) Full

In combination with standard cytarabine and anthracycline induction and standard cytarabine consolidation chemotherapy, followed by quizartinib single-agent maintenance therapy for adult patients with newly diagnosed acute myeloid leukaemia (AML) that is FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) positive.

11/11/2024 01/10/2024 axicabtagene ciloleucel (Yescarta) Resubmission

Treatment of adult patients with diffuse large B‑cell lymphoma (DLBCL) and high-grade B-cell lymphoma (HGBL) that relapses within 12 months from completion of, or is refractory to, first-line chemoimmunotherapy.

11/11/2024 01/10/2024 pembrolizumab (Keytruda) Full

In combination with platinum-containing chemotherapy as neoadjuvant treatment, and then continued as monotherapy as adjuvant treatment, for the treatment of resectable non‑small cell lung carcinoma at high risk of recurrence in adults.

09/12/2024 05/11/2024 zanubrutinib (Brukinsa) Full

As monotherapy is indicated for the treatment of adult patients with marginal zone lymphoma (MZL) who have received at least one prior anti-CD20-based therapy.

TBC 10/01/2023 levodopa/carbidopa/entacapone (Lecigon) Full

For treatment of advanced Parkinson's disease with severe motor fluctuations and hyperkinesia or dyskinesia when available oral combinations of Parkinson medicinal products have not given satisfactory results

TBC 06/08/2024 fosdenopterin (Nulibry) Ultra-orphan initial assessment

Treatment of patients with molybdenum cofactor deficiency (MoCD) Type A.

TBC TBC relugolix / estradiol / norethisterone acetate (Ryeqo) Full

In adult women of reproductive age for symptomatic treatment of endometriosis in women with a history of previous medical or surgical treatment for their endometriosis.

TBC futibatinib (Lytgobi) Abbreviated

For treatment of adult patients with locally advanced or metastatic cholangiocarcinoma with a fibroblast growth factor receptor 2 (FGFR2) fusion or rearrangement that have progressed after at least one prior line of systemic therapy.

TBC 03/09/2024 maralixibat (Livmarli) Full

For treatment of cholestatic pruritus in patients with Alagille syndrome (ALGS) 2 months of age and older.

TBC TBC danicopan (Voydeya) Full

As an add-on to ravulizumab or eculizumab for the treatment of adult patients with paroxysmal nocturnal haemoglobinuria (PNH) who have residual haemolytic anaemia.

TBC TBC iptacopan (Fabhalta) Full

Paroxysmal nocturnal hemoglobinuria (PNH), who have haemolytic anaemia.

TBC TBC durvalumab (Imfinzi) Full

In combination with platinum-based chemotherapy as neoadjuvant treatment, followed by durvalumab as monotherapy after surgery, is indicated for the treatment of adults with resectable (tumours ≥ 4 cm and/or node-positive) NSCLC and no known EGFR mutations or ALK rearrangements.

TBC TBC donanemab (Kisunla) Full

For the treatment of mild cognitive impairment (MCI) due to Alzheimer’s disease (AD) or mild dementia caused by AD.
[To be confirmed when MA granted]

TBC TBC lecanemab (Leqembi) Full

To slow progression of mild cognitive impairment and mild dementia due to Alzheimer’s disease in adults.

TBC TBC fidanacogene elaparvovec (Beqvez) Full

Treatment of severe and moderately severe haemophilia B (congenital factor IX deficiency) in adult patients without a history of factor IX inhibitors and without detectable antibodies to variant AAV serotype Rh74.

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