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SMC ID Date Medicine Submission Type Indication
SMC2733 07/07/2025 selpercatinib (Retsevmo) Full

As monotherapy for the treatment of adults and adolescents 12 years and older with advanced RET fusion-positive thyroid cancer who are radioactive iodine-refractory (if radioactive iodine is appropriate).

SMC2474 10/10/2022 pembrolizumab (Keytruda) Full

Pembrolizumab in combination with lenvatinib, for the treatement of advanced or recurrent endometrial carcinoma (EC) in adults who have disease progression on or following prior treatment with a platinum containing therapy in any setting and who are not candidates for curative surgery or radiation.

SMC2476 13/06/2022 lenvatinib (Kisplyx) Abbreviated

In combination with pembrolizumab for the first‑line treatment of advanced renal cell carcinoma in adults

SMC2370 13/09/2021 selpercatinib (Retsevmo) Full

Adults and adolescents 12 years and older with advanced RET-mutant medullary thyroid cancer (MTC) who require systemic therapy following prior treatment with cabozantinib and/or vandetanib.
Adults with advanced RET fusion-positive thyroid cancer (TC) who require systemic therapy following prior treatment with lenvatinib and/or sorafenib.

SMC2199 11/11/2019 lenvatinib (Kisplyx) Full

In combination with everolimus for the treatment of adult patients with advanced renal cell carcinoma (RCC) following one prior vascular endothelial growth factor (VEGF)-targeted therapy.

SMC2138 08/04/2019 lenvatinib (Lenvima) Full

as monotherapy for the treatment of adult patients with advanced or unresectable hepatocellular carcinoma (HCC) who have received no prior systemic therapy

1179/16 10/10/2016 lenvatinib (Lenvima) Full treatment of adult patients with progressive, locally advanced or metastatic, differentiated (papillary/follicular/Hürthle cell) thyroid carcinoma (DTC), refractory to radioactive iodine (RAI).

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