following a full submission:
anakinra (Kineret®) is accepted for use within NHSScotland.
Indication under review: in adults, adolescents, children and infants aged eight months and older with a body weight of 10kg or above for the treatment of Still’s disease, including Systemic Juvenile Idiopathic Arthritis (SJIA) and Adult-Onset Still’s Disease (AOSD), with active systemic features of moderate to high disease activity, or in patients with continued disease activity after treatment with non-steroidal anti-inflammatory drugs (NSAIDs) or glucocorticoids. Anakinra can be given as monotherapy or in combination with other anti-inflammatory drugs and disease-modifying anti-rheumatic drugs (DMARDs).
Anakinra was superior to placebo in achieving a modified American College of Rheumatology paediatric (mACRpedi) 30 response in patients with SJIA reliant on corticosteroids for disease control. Anakinra and DMARDs were associated with a similar remission rate in patients with AOSD following eight weeks of treatment.
Medicine details
- Medicine name:
- anakinra (Kineret)
- SMC ID:
- SMC2104
- Indication:
- Kineret is indicated in adults, adolescents, children and infants aged 8 months and older with a body weight of 10kg or above for the treatment of Still’s disease, including Systemic Juvenile Idiopathic Arthritis (SJIA) and Adult-Onset Still’s Disease (AOSD), with active systemic features of moderate to high disease activity, or in patients with continued disease activity after treatment with non-steroidal anti-inflammatory drugs (NSAIDs) or glucocorticoids. Kineret can be given as monotherapy or in combination with other anti-inflammatory drugs and disease-modifying antirheumatic drugs (DMARDs).
- Pharmaceutical company
- Swedish Orphan
- BNF chapter
- Musculoskeletal and joint diseases
- Submission type
- Full
- Status
- Accepted
- Date advice published
- 08 October 2018