Indication

Treatment of metachromatic leukodystrophy characterized by biallelic mutations in the ARSA gene leading to a reduction of the ARSA enzymatic activity:

  • in children with late infantile or early juvenile forms, without clinical manifestations of the disease
  • in children with the early juvenile form, with early clinical manifestations of the disease, who still have the ability to walk independently and before the onset of cognitive decline

Medicine details

Medicine name:
atidarsagene autotemcel (Libmeldy)
SMC ID:
SMC2886
Pharmaceutical company
Orchard Therapeutics
BNF chapter
Nutrition and blood
Submission type
Ultra-orphan reassessment
Publication due date:
TBC
SMC meeting date:
TBC
Patient group submission deadline:
TBC