eltrombopag (Revolade)

following a full submission:

eltrombopag (Revolade®) is accepted for use within NHS Scotland.

Indication under review: In adult patients with chronic hepatitis C virus infection, for the treatment of thrombocytopenia, where the degree of thrombocytopenia is the main factor preventing the initiation or limiting the ability to maintain optimal interferon-based therapy.

Two double-blind, randomised, controlled studies in patients with chronic hepatitis C virus infection and thrombocytopenia demonstrated significantly higher sustained viral response rates in patients who continued treatment with eltrombopag during interferon-based antiviral therapy than in those patients whose eltrombopag treatment was discontinued on initiation of antiviral therapy.

This SMC advice takes account of the benefits of a Patient Access Scheme (PAS) that improves the cost-effectiveness of eltrombopag. This SMC advice is contingent upon the continuing availability of the Patient Access Scheme in NHS Scotland or a list price that is equivalent or lower.