etravirine (Intelence)

Following a resubmission

etravirine (Intelence), in combination with a boosted protease inhibitor and other antiretroviral medicinal products, is accepted for use within NHS Scotland for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in antiretroviral treatment experienced adult patients.

In HIV-1 infected adults, with resistance to currently available non-nucleoside reverse transcriptase inhibitors (NNRTIs) and at least three primary protease inhibitor (PI) mutations, who were receiving an optimised background regimen that included boosted darunavir plus nucleoside reverse transcriptase inhibitors (NRTIs) and optional enfuvirtide, etravirine achieved significant improvements in virological, immunological and clinical outcomes when compared with placebo.