panobinostat (Farydak)

following a full submission considered under the end of life and orphan process: 

panobinostat (Farydak®) is accepted for use within NHS Scotland.

Indication under review: In combination with bortezomib and dexamethasone, for the treatment of adult patients with relapsed and/or refractory multiple myeloma who have received at least two prior regimens including bortezomib and an immunomodulatory agent.

In patients with relapsed or relapsed and refractory multiple myeloma, panobinostat in combination with bortezomib plus dexamethasone was associated with a significant benefit in progression-free survival (PFS) compared with bortezomib plus dexamethasone. The treatment effect of the panobinostat containing regimen on PFS was greater in the subgroup of patients’ representative of the licensed indication. 

This SMC advice takes account of the benefits of a Patient Access Scheme (PAS) that improves the cost-effectiveness of panobinostat. This advice is contingent upon the continuing availability of the PAS in NHS Scotland or a list price that is equivalent or lower.