sacituzumab govitecan (Trodelvy)

following a full submission assessed under the end of life and orphan equivalent process:

sacituzumab govitecan (Trodelvy®) is accepted for use within NHSScotland.

Indication under review: Treatment of adult patients with unresectable locally advanced or metastatic triple-negative breast cancer (mTNBC) who have received two or more prior lines of systemic therapies, at least one of them given for unresectable locally advanced or metastatic disease.

Sacituzumab govitecan, compared with a range of single-agent chemotherapies, significantly improved progression free survival and overall survival in adults with mTNBC, without brain metastases, who had received at least two prior chemotherapy regimens including a taxane.

This advice applies only in the context of an approved NHSScotland Patient Access Scheme (PAS) arrangement delivering the cost-effectiveness results upon which the decision was based, or a PAS/ list price that is equivalent or lower.

This advice takes account of the views from a Patient and Clinician Engagement (PACE) meeting