following a full submission assessed under the end of life and orphan equivalent medicine process:
selpercatinib (Retsevmo®) is not recommended for use within NHSScotland.
Indication under review: as monotherapy for the treatment of adults with advanced RET fusion-positive non-small cell lung cancer (NSCLC) who require systemic therapy following prior treatment with immunotherapy and/or platinum-based chemotherapy.
In a phase I/II study, in previously treated patients with RET-fusion positive NSCLC, selpercatinib was associated with an objective response rate of 64%.
The submitting company’s justification of the treatment’s cost in relation to its health benefits was not sufficient and in addition the company did not present a sufficiently robust economic case to gain acceptance by SMC.
This advice takes account of the views from a Patient and Clinician Engagement (PACE) meeting.
Medicine details
- Medicine name:
- selpercatinib (Retsevmo)
- SMC ID:
- SMC2371
- Indication:
As monotherapy for the treatment of adults with advanced rearranged during transfection (RET) fusion-positive non-small cell lung cancer (NSCLC) who require systemic therapy following prior treatment with immunotherapy and/or platinum-based chemotherapy.
- Pharmaceutical company
- Eli Lilly and Company Ltd
- BNF chapter
- Malignant disease and immunosuppression
- Submission type
- Full
- Status
- Not recommended
- Date advice published
- 08 November 2021