vildagliptin (Galvus)

Following a full submission

vildagliptin (Galvus) is accepted for use within NHS Scotland for the treatment of type 2 diabetes mellitus as dual oral therapy in combination with a sulphonylurea, in patients with insufficient glycaemic control despite maximal tolerated dose of a sulphonylurea or for whom metformin is inappropriate due to contraindications or intolerance.

When added to a sulphonylurea, vildagliptin had a modest beneficial effect on glycated haemoglobin (HbA1C).

Vildagliptin is also licensed for use in combination with metformin or thiazolidinedione drugs for the treatment of type 2 diabetes. SMC has already issued advice on use in combination with metformin. As this submission from the manufacturer related only to the use of vildagliptin in combination with a sulphonylurea, SMC cannot recommend the use of vildagliptin in combination with thiazolidinedione drugs.